Fig. 10

FGFR3 alterations in human breast cancer. Frequency of FGFR3 alterations in breast cancer patients analysed using two breast cancer patient datasets, a, Pan-cancer Atlas dataset from TCGA and b, METABRIC dataset, using cBioportal (note that no mutation data are available for the METABRIC dataset). Only patients with FGFR3 alterations are displayed for brevity. For both cohorts, the breast cancer subtypes based on ER/PR and HER2 receptor status are displayed. c, A Kaplan–Meier plot showing patients with amplification and/or overexpression of FGFR3 (n = 46) are significantly associated with worse overall survival compared to those without these alterations (n = 1857) in the METABRIC dataset. A Logrank test was used, P-value = 0.0204 (P-value < 0.05 considered significant). Survival data for the two patient groups were extracted and downloaded from cBioportal, and survival analysis performed using in-house Matlab script